Escitalopram/Lexapro

Escitalopram is an SSRI antidepressant that works by blocking serotonin reuptake, which increases serotonin levels in the brain. Serotonin is a neurotransmitter that regulates mood, emotions, and anxiety. By enhancing serotonin availability, escitalopram helps stabilize mood and reduce symptoms of depression and anxiety.

Escitalopram is FDA-approved for treating major depressive disorder (MDD) and generalized anxiety disorder (GAD). It is also commonly prescribed off-label for panic disorder, social anxiety disorder, OCD, PMDD, and PTSD.

• Persistent sadness, low mood, or hopelessness
• Excessive worry or anxiety
• Panic attacks and social anxiety
• Irritability and mood swings
• Trouble sleeping due to anxiety
• Obsessive thoughts and compulsive behaviors (OCD)

Escitalopram is one of the most commonly prescribed SSRIs due to its effectiveness and lower risk of side effects compared to other antidepressants. However, individual responses vary, and it may take 4-6 weeks to see full benefits.

• Depression and anxiety disorders – often taken for at least 6-12 months; long-term use may be recommended for recurrent cases.
• Panic disorder, OCD, PTSD – duration varies based on symptom severity and treatment response.

Escitalopram has been shown to be highly effective for depression and anxiety, with many patients experiencing significant improvement in mood and emotional stability. Studies suggest that it is better tolerated and slightly more effective than other SSRIs such as fluoxetine (Prozac) and sertraline (Zoloft) in some cases.

Escitalopram does not change personality but helps balance mood and reduce anxiety. Some people report feeling “more like themselves” as their symptoms improve.

Common side effects include:

• Nausea
• Headaches
• Drowsiness or fatigue
• Increased sweating
• Sexual dysfunction (decreased libido, difficulty reaching orgasm)

Rare but serious side effects:

• Increased risk of suicidal thoughts in young adults
• Serotonin syndrome (when combined with other serotonergic drugs)
• Increased risk of bleeding (especially when taken with NSAIDs or blood thinners)

Yes, stopping escitalopram suddenly can lead to SSRI withdrawal symptoms such as dizziness, nausea, irritability, brain “zaps,” and flu-like symptoms. A gradual tapering under medical supervision is recommended.

Escitalopram is classified as Pregnancy Category C, meaning potential risks should be weighed against benefits. Some studies suggest a small risk of neonatal withdrawal symptoms or persistent pulmonary hypertension in newborns. It passes into breast milk, so caution is advised for nursing mothers.

Escitalopram is not addictive, but discontinuing it abruptly can cause withdrawal symptoms. It should always be stopped gradually under medical supervision.

The FDA has approved escitalopram for major depressive disorder and generalized anxiety disorder. It carries a black box warning about the increased risk of suicidal thoughts and behaviors in children, adolescents, and young adults.